Product ID:LIPOPOLYSACCHARIDE E COLI J5, 437620
MSDS Date:04/27/1999
FSC:6505
NIIN:00N092957
Status Code:A
MSDS Number: CJWVX

Emergency Phone: 202-783-7616

Info Phone: 619-450-5558; 800-854-3417

Cage: 29089

Telephone: 619-450-5558; 800-854-3417

Cage: 29089

LIPOPOLYSACCHARIDE; (LIPOPOLYSACCHARIDE, E. COLI J5)

RTECS: UX2990000

Routes of Entry: Inhalation:YES Skin:YES Ingestion:YES
Reports of Carcinogenicity:NTP:NO IARC:NO OSHA:NO
Health Hazards Acute and Chronic:ACUTE: MAY BE HARMFUL BY INGESTION,
INHALATION OR ABSORPTION THROUGH SKIN. MATERIAL MAY BE HARMFUL IF
ALLOWED TO CONTAMINATE OPEN CUTS OR WOUNDS. MATERIAL IS HIGHLY
PYROGENIC; MAY CAUSE FEVER. CHRONIC : THERE IS LIMITED EVIDENCE
THAT LIPOPOLYSACCHARIDES ARE TERATOGENIC IN LABORATORY ANIMALS.
UNTIL FURTHER TESTING HAS BEEN DONE, THEY SHOULD BE TREATED AS
POSSIBLE TERATOGENS IN HUMANS.
Effects of Overexposure:SEE HEALTH HAZARDS.

First Aid:SKIN: WASH WITH COPIOUS AMOUNTS OF WATER FOR AT LEAST 15
MINUTES. REMOVE CONTAMINATED CLOTHING AND SHOES AND WASH BEFORE
WEARING. CONSULT A PHYSICIAN. EYE: FLUSH WITH COPIOUS AMOUNTS OF
WATER FOR AT L EAST 15 MINUTES. ASSURE ADEQUATE FLUSHING BY
SEPARATING THE EYELIDS WITH FINGERS. CONSULT A PHYSICIAN.
INHALATION: REMOVE TO FRESH AIR AND MONITOR BREATHING. IF BREATHING
BECOMES DIFFICULT, GIVE OXYGE N AND CONSULT A PHYSICIAN. IF
BREATHING STOPS, GIVE ARTIFICIAL RESPIRATION AND CONSULT A
PHYSICIAN. INGESTION: WASH MOUTH OUT WITH WATER AND CONSULT THE
LOCAL POISON CENTER AND A PHYSICIAN.

Extinguishing Media:DRY CHEMICAL POWDER, CARBON DIOXIDE, WATER SPRAY,
ALCOHOL OR POLYMER FOAM.
Fire Fighting Procedures:USE NIOSH APPROVED SCBA & FULL PROTECTIVE
EQUIPMENT .
Unusual Fire/Explosion Hazard:UPON THERMAL DECOMPOSITION, IT MAY EMIT
TOXIC GASES.

Spill Release Procedures:WEAR NIOSH APPROVED SELF-CONTAINED BREATHING
APPARATUS, RUBBER BOOTS, AND HEAVY RUBBER GLOVES. SWEEP UP AND
PLACE IN A SUITABLE CONTAINER. AVOID RAISING DUST. HOLD FOR
APPROPRIATE DISPOSAL. WASH SPILL SITE AND VENTILATE AREA AFTER
MATERIAL PICKUP IS COMPLETE.

Handling and Storage Precautions:STORE IN A TIGHTLY CLOSED CONTAINER IN
A +4C REFRIGERATOR. MATERIAL IS TOXIC. POSSIBLE TERATOGEN. DO NOT
WORK WITH MATERIAL IF SKIN IS CUT OR SCRATCHED. AVOID CONTACT WITH
MATERIAL. AVOID PROLONGED OR REPEATED EXPOSURE. LAB SHOULD BE
EQUIPPED WITH A SAFETY SHOWER AND EYE WASH STATION.

Respiratory Protection:USE A NIOSH APPROVED RESPIRATOR.
Ventilation:HANDLE IN A CHEMICAL FUME HOOD WITH ADEQUATE VENTILATION.
Protective Gloves:CHEMICAL RESISTANT GLOVES.
Eye Protection:ANSI APPROVED CHEMICAL WORKERS GOGGLES .
Other Protective Equipment:EYE WASH AND DELUGE SHOWER MEETING ANSI
DESIGN CRITERIA .
Work Hygienic Practices:WASH THOROUGHLY AFTER HANDLING MATERIAL.
Supplemental Safety and Health
PHYSICAL DATA: SOLUBILITY: SOLUBLE IN 0.5% TRIETHYLAMINE.

Solubility in Water:SUPDAT
Appearance and Odor:LYOPHILIZED SOLID.

Stability Indicator/Materials to Avoid:YES
NOT APPLICABLE.
Stability Condition to Avoid:NOT APPLICABLE.
Hazardous Decomposition Products:UPON THERMAL DECOMPOSITION, MAY EMIT
TOXIC GASES INCLUDING CARBON MONOXIDE, CARBON DIOXIDE, AND NITROGEN
OXIDES.

Waste Disposal Methods:COUNTRY, FEDERAL, STATE, AND LOCAL REGULATIONS
ARE VARIED AND CHANGE FREQUENTLY. FOR THIS REASON, MFR RECOMMENDS
THAT YOU CONTACT YOUR LOCAL DEPARTMENT OF HEALTH SERVICES FOR
INFORMAITON ON THE DISPOS AL OF THIS PRODUCT OR ARRANGE FOR
DOSPOSAL BY A LICENSED DISPOSAL COMPANY.

Toxicological Information:NOTE: TO BEST OF MFR'S KNOWLEDGE, TOX
PROPERTIES OF LIPOPOLYSACCHARIDE, E COLI J5 HAVE NOT BEEN
THOROUGHLY INVESTIGATED. INFO BELOW PERTAINS TO LIPOPOLYSACCHARIDE
FROM WILD TYPE STRAIN, LIPOPOLYSACCH ARIDE, E. COLI 0111:B4. RTECS
NUMBER: OJ0895400 (LIPOPOLYSACCHARIDE, E. COLI 0111:B4). TOX DATA &
REFERENCES:ORL; RAT; LD50: 48300 UG/KG 1994. KOREAN BIOCHEMICAL
JOURNAL. 27,413. ORL; MUS; LD50: 5630 0 UG/KG 1994. KOREAN
BIOCHEMICAL JOURNAL. 27,413. IPR; RAT; LD50: 10 MG/KG 1962.
PROCEEDINGS OF SOCIETY OF EXPERIMENTAL BIOLOGY & MEDICINE. 109,429.
IVN; MUS; LD50: 7670 UG/KG 1982. MICROBIOLOGY & IMM UNOLOGY. (STATE
REGULATORY INFO)

Disclaimer (provided with this information by the compiling agencies):
This information is formulated for use by elements of the Department
of Defense. The United States of America in no manner whatsoever,
expressly or implied, warrants this information to be accurate and
disclaims all liability for its use. Any person utilizing this
document should seek competent professional advice to verify and
assume responsibility for the suitability of this information to their
particular situation.

Ecological:NO INFORMATION AVAILABLE.

Transport Information:UN NUMBER: UN3172. PROPER SHIPPING NAME: TOXINS,
EXTRACTED FROM LIVING SOURCES, SOLID, N.O.S. IATA CLASS: 6.1. IATA
PACKING GROUP: III.

SARA Title III Information:N/P. --STATE REGULATORY INFO: BULLETIN OF
THE INSTITUTE OF HYGIENIC SCIENCES. (99), 68. IVN; MUS; DOSE: 4
UG/KG POST-IMPLANTATION MORTALITY 1990. JOURNAL OF REPRODUCTION AND
FERTILITY. 90,395. REFER T O THE REGISTRY OF TOXIC EFFECTS OF
CHEMICAL SUBSTANCES (RTECS) FOR A DEFINITION OF ABBREVIATIONS USED
IN THE ABOVE TEXT AND FOR ADDITIONAL INFORMATION. THIS REPORT
CONTAINS ONLY SELECTED INFORMATION F ROM THE RTECS.
Federal Regulatory Information:REGULATORY INFORMATION: T. RISK PHRASES:
R23/24/25: TOXIC BY INHALATION, IN CONTACT WITH SKIN AND IF
SWALLOWED. R47: MAY CAUSE BIRTH DEFECTS. SAFETY PHRASES: S22: DO
NOT BREATHE DUST. S24/25: AVOID CO NTACT WITH SKIN AND EYES.
S36/37/39: WEAR SUITABLE PROTECTIVE CLOTHING, GLOVES AND EYE/FACE
PROTECTION. S45: IN CASE OF ACCIDENT OF IF YOU FEEL UNWELL, SEEK
MEDICAL ADVICE IMMEDIATELY. S53: AVOID EXPO SURE-OBTAIN SPECIAL
INSTRUCTIONS BEFORE USE.
State Regulatory Information:N/P. --TOXICOLOGICAL INFORMATION: 26,455.
REPRODUCTIVE EFFECTS & REFERENCES: IPR; RAT; DOSE: 500 UG/KG
FETOTOXICITY; FETAL DEATH 1962. PROCEEDINGS OF THE SOCIETY FOR
EXPERIMENTAL BIOLOGY AND MEDICINE. 109,429. IPR; RAT; DOSE: 1
MG/KG POST-IMPLANTATION MORTALITY 1962. PROCEEDINGS OF THE SOCIETY
FOR EXPERIMENTAL BIOLOGY AND MEDICINE. 109,429. IVN; RAT; DOSE:
100 UG/KG FETOTOXICITY; FETAL DEATH; EXT RA EMBRYONIC STRUCTURES;
POST-IMPLANTATION MORTALITY; 1981. EISEI SHIKENJO HOKOKU. BULLETIN
OF THE I NSTITUTE OF HYGIENIC SCIENCES. (99), 68. IVN; RAT; DOSE: 1
UG/KG TOXIC EFFECTS ON LITTER SIZE 1981. EISEI SHIKENJO HOKOKU.
(SARA TITLE III)